Withdrawal of biologic agents in rheumatoid arthritis: a systematic review and meta-analysis

Tais Freire Galvao1 & Ivan Ricardo Zimmermann2 & Licia Maria Henrique da Mota3 &
Marcus Tolentino Silva4,5 & Mauricio Gomes Pereira2

Received: 12 January 2016 /Revised: 14 April 2016 /Accepted: 16 April 2016

# International League of Associations for Rheumatology (ILAR) 2016

Abstract The aim of this study is to assess the efficacy of  withdrawing biologics from patients with rheumatoid arthritis in sustained remission or low disease activity. This is a systematic
review of clinical trials that randomized withdrawal or continuation of biologics. We searched MEDLINE, Embase, leia o artigo todo.